Gonadotropic cell

Gonadotropic cell
Code TH H3.08.02.2.00004

Gonadotropes are endocrine cells in the anterior pituitary that produce the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Release of FSH and LH by gonadotrophs is regulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus.[1]

Gonadotropes appear basophilic in histological preparations.

Gonadotropes have insulin receptors, which can be overstimulated by too high insulin levels. This may lead to infertility as homone release levels are disrupted. [2]

References

  1. ^ Ganong, William F.: "Review of Medical Physiology", page 248. Lange, 2005.
  2. ^ Brothers, K. J.; Wu, S.; Divall, S. A.; Messmer, M. R.; Kahn, C. R.; Miller, R. S.; Radovick, S.; Wondisford, F. E. et al. (2010). "Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor (IR)". Cell Metabolism 12 (3): 295–305. doi:10.1016/j.cmet.2010.06.010. PMC 2935812. PMID 20816095. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2935812.  edit